Stocksignals
NETFLIX starting the 2nd bullish leg of its expansion phase.Netflix (NFLX) has been consolidating above the 1D MA50 (blue trend-line) since the August 20 High and is on the exact same level where during all previous Bullish Legs of the 2-year Channel Up, it ended the consolidation and moved to the 2nd rally of the expansion phase.
This is also evident on the 1D RSI, which is about to start a Channel Down that in previous Legs it moved parallel with the price's 2nd rally. Our Target is $900.00 representing a +70.48% rise from April's low, which is the smallest rally recorded within the 2-year Channel Up, thus the more realistic target.
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S&P500 The Bull Cycle is still far from over!Six months ago while the market was undecided about whether or not the S&P500 (SPX) rally would continue, we presented a very useful multi-year chart on the 1M time-frame (February 27, see chart below), where we called for an extension of the uptrend, claiming confidently that the 'Bull Cycle is far from over':
As you can see those who bought without fear have enjoyed so far more than +15% gains. What's even more impressive is the massive bullish reversal of the August candle, that managed to close the month in green, despite the early aggressive sell-off.
This is a strong sign that the rally is far from over, but it's not the only one. The key here, and constitutes our main modification relative to the chart 6 months ago, is that the most accurate sell signal on a cyclical basis has been historically given after the 1M RSI breaks above the 70.00 overbought barrier and posts Lower Highs.
This signal has had 100% accuracy in the past 10 years, effectively projecting the 2015, 2018 and 2022 corrections. The 1M RSI also has a Channel Down Resistance to consider but the Lower Highs signal should be top priority for investors to start selling.
As a result, we expect the index to surpass the 6000 mark and even approach 6500, before we consider a cyclical selling sequence again.
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Axis bank has a chance to ace it..Axis Bank Ltd. engages in banking and financial services. It provides financial solutions to retail, small and medium enterprises, government, and corporate businesses. It operates through the following segments: Treasury, Retail Banking, Corporate or Wholesale Banking, and Other Banking Business. The Other Banking Business segment encompasses para banking activities such as third party product distribution advisory and other banking transactions.
Axis Bank Ltd. CMP is 1188.80. The positive aspects of the company are low Valuation (P.E. =13.8), Company with Zero Promoter Pledge, Increasing Revenue every Quarter for the past 8 Quarters, Mutual Funds Increased Shareholding over the Past Two Months, MFs increased their shareholding last quarter and Book Value per share Improving for last 2 years. The Negative aspects of the company are Poor cash generated from core business, declining Cash Flow from Operations and Increase in Provisions in the recent results.
Entry can be taken after closing above 1191 Targets in the stock will be 1206, 1243 and 1270. The long-term target in the stock will be 1292, 1313 and 1337. Stop loss in the stock should be maintained at Closing below 1127.
The above information is provided for educational purpose, analysis and paper trading only. Please don't treat this as a buy or sell recommendation for the stock. We do not guarantee any success in highly volatile market or otherwise. Stock market investment is subject to market risks which include global and regional risks. We will not be responsible for any Profit or loss that may occur due to any financial decision taken based on any data provided in this message.
Canara Bank Can start after consolidation.Canara Bank engages in the provision of commercial banking and financial services. It operates through the following segments: Treasury, Corporate or Wholesale Banking, Retail Banking, and Other Banking Business.
Canara Bank CMP is 112.77 The positive aspects of the company are low Valuation (P.E. =6.5), Annual Profit Growth higher than Sector Profit Growth, Increasing profits every quarter for the past 2 quarters, Company with Zero Promoter Pledge, Mutual Funds Increased Shareholding over the Past Two Months and FII / FPI or Institutions increasing their shareholding. The share has good dividend yield of 2.9% at CMP. The Negative aspects of the company is that the stocks is underperforming their Industry Price.
Entry can be taken after closing above 114 Targets in the stock will be 117 and 122. The long-term target in the stock will be 124 and 129. Stop loss in the stock should be maintained at Closing below 105.
The above information is provided for educational purpose, analysis and paper trading only. Please don't treat this as a buy or sell recommendation for the stock. We do not guarantee any success in highly volatile market or otherwise. Stock market investment is subject to market risks which include global and regional risks. We will not be responsible for any Profit or loss that may occur due to any financial decision taken based on any data provided in this message.
BLUE STAR - Short Trade - Target 2 Done!BLUE STAR - Short Trade - Target 2 Done!
Entry at 1721
Stoploss: 1744
Trailing stoploss: 1705
Potential to reach 1582
Potential profit: 7.7%
Profit so far: 3.6%
Current status: Hold the short trade with trailing stoploss set at 1705
Please consider following for more tips, trade setups and analysis.
Namaste!
NMDC SHORT Trade Setup and levelsNMDC SHORT Trade Setup and levels
Got a clear short entry on 28 August
Entry: 226
Stoploss: 230
Target 1: 222 (DONE)
Target 2: 215 (DONE)
Target 3: 208
Target 4: 204
Current Trailing Stop loss: 224
Hope this helps.
Support my work by following my profile for more such actionable charts.
RIVIAN giving highly accurate signals within this Channel Down.Rivian Automotive (RIVN) couldn't have been giving us more accurate signals since May (see charts below), as not only did we get a timely entry at the bottom (chart 1, May 17) but also sold at the very top (June 26 chart 2) of the Channel Down:
Right now we face a technical similarity with September 2023, exactly 1 year ago, where the price failed to utilize the 1D MA50 (blue trend-line) as Support and started a new long-term Bearish sequence.
However we do realize the potential long-term trend changing effect that a potential new cycle of interest rate cuts might have in two weeks, so again our trading plan will prepare for both scenarios with clear break-out signals and levels.
Obviously as long as the price remains within the 2-year Channel Down, the trend is bearish and the action will be 'sell on every high'. The Sell Signal on the September 2023 fractal was given when the 1D RSI hit the 60.00 level (red arrow, Sep 14 2023). Naturally we will wait for another such trigger to sell and Target 10.55 on the 0.5 Fibonacci retracement level, which is where last year's sell signal bottomed (October 30 2023).
If on the other hand, the price closes a 1W candle above the 1W MA100 (yellow trend-line), we will buy that clear long-term bullish break-out signal and Target 28.00 (just below Resistance 2). This could emerge as a Channel Up pattern.
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INDIAMART BUY VIEW Good Potential Stock - INDIAMART Buy Now
Trade Reason :
1) Weekly - Buying view - Market uptrend and Take support
2) Fib Retracement - 0.50 % correction Completed
3)Day Timeframe - Trend Reversed
4)Aggressive Trader - Entry Now
5)Conservative Trader - Wait for Little Correction in DAY timeframe
Entry - 2905 Rs
Stoploss - 2625 Rs
Target 1 - 3032 Rs
Target 2 - 3226 Rs
Use Proper Risk management ... Happy Trading
Powergrid can become PowerfulPower Grid Corp. of India Ltd. is a holding company, which engages in the power transmission business. It operates through the following segments: Transmission Services, Consultancy Services, and Telecom Services. It is a PSU company with high dividend yield of 3.3% at current market price.
Power Grid Corp. of India Ltd. CMP is 337.40 The positive aspects of the company are moderate Valuation (P.E. =20), Company with Zero Promoter Pledge, MFs increased their shareholding last quarter, Growth in Quarterly Net Profit with increasing Profit Margin and The Negative aspects of the company are Inefficient use of shareholder funds - ROE declining in the last 2 years and Declining Net Cash Flow : Companies not able to generate net cash.
Entry can be taken after closing above 343. Targets in the stock will be 348 and 356. The long-term target in the stock will be 364. Stop loss in the stock should be maintained at Closing below 328 or 291 depending on your risk taking ability.
The above information is provided for educational purpose, analysis and paper trading only. Please don't treat this as a buy or sell recommendation for the stock. We do not guarantee any success in highly volatile market or otherwise. Stock market investment is subject to market risks which include global and regional risks. We will not be responsible for any Profit or loss that may occur due to any financial decision taken based on any data provided in this message.
Ultratech may make not ultra but mild upward moves. UltraTech Cement Ltd. is a holding company, which engages in the manufacture and sale of cement and cement related products. Its products include ordinary portland cement, portland blast furnace slag cement, white cement, and ready mix concrete.
UltraTech Cement Ltd. CMP is 11301.90. The positive aspects of the company are Company with Low Debt, Company with Zero Promoter Pledge, Book Value per share Improving for last 2 years. The Negative aspects of the company are high Valuation (P.E. =46.5), PE higher than Industry PE, MFs decreased their shareholding last quarter, Declining Net Cash Flow : Companies not able to generate net cash.
Entry can be taken after closing above 11380. Targets in the stock will be 11524 and 11707. The long-term target in the stock will be 11893 and 12096. Stop loss in the stock should be maintained at Closing below 10922.
The above information is provided for educational purpose, analysis and paper trading only. Please don't treat this as a buy or sell recommendation for the stock. We do not guarantee any success in highly volatile market or otherwise. Stock market investment is subject to market risks which include global and regional risks. We will not be responsible for any Profit or loss that may occur due to any financial decision taken based on any data provided in this message.
SMCI This is honestly the last stand.Super Micro Computer Inc. (SMCI) suffered yet another brutal sell-off following the announcement of a delay in filing its 10-K annual report. This may prove to be a catastrophic one as technically not only did it fail exactly on its 1W MA50 (blue trend-line) but also saw the stock test the bottom of its multi-year parabolic support, the Higher Lows Zone since the week of July 05 2022.
This was basically the last time the 1W MA100 (green trend-line) got tested with the current week coming the closest since then. The 1W MA100 last broke during the unexpected COVID flash crash in March 2020, so technically it is the stock's longest Support. If it fails to hold and SMCI closes a 1W candle below it, the long-term parabolic growth pattern is invalidated and we will risk testing the 1W MA200 (orange trend-line) at a price potentially around $250.00.
If on the other hand the 1W MA100 holds (and we will need the news sentiment to drastically reverse in order to achieve that, something that currently can't be seen on the horizon), then we can see another +400% long-term rally, in which case we estimate a Target around $2000, the stock's next critical psychological growth level.
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TEVA Pharmaceutical is a BUY?As the excitement around AI continues to wane, concerns about a potential US recession grow, and the risks of a major conflict in the Middle East linger, Teva Pharmaceutical's stock is entering an accumulation phase above $18, signaling strong bullish sentiment.
Why Wall Street's bullish in this drug company ?
First, on July 31, Teva announced its financial results for the second quarter of 2024, demonstrating that the company remains resilient despite years of investor disappointment following the Allergan Generics acquisition and the loss of Copaxone exclusivity.
However, over the past 18 months, under Richard Francis' leadership, the company has shown significant growth, with increasing revenue and profits in its European and US segments, the successful launch of biosimilars and Uzedy, and record sales of Austedo, its blockbuster treatment for certain neurological disorders.
Alongside rising sales of generics, Teva has also accelerated the development of innovative medications, which could set new standards in treating schizophrenia and some chronic inflammatory diseases.
For instance, on July 25, the company delighted investors by announcing that it had completed patient enrollment ahead of schedule in a Phase 2b clinical trial assessing the efficacy and safety of duvakitug for treating ulcerative colitis and Crohn's disease, driven by strong interest from healthcare professionals and patients.
Teva Pharmaceutical's financial performance and 2024 outlook
After years of challenges, the Teva revenue exceeded $4 billion once again, reaching $4.14 billion in the second quarter of 2024, a 7.4% year-on-year increase that surpassed consensus estimates by $114 million.
Meanwhile, another critical financial metric, earnings per share aka EPS, exceeded my expectations despite rising costs associated with conducting expensive clinical trials for assessing the efficacy of Teva's biosimilars and experimental drugs targeting neurodegenerative and autoimmune disorders. The Israeli company's EPS reached $0.61 for the three months ending June 30, 2024, marking a 27.1% increase from the previous quarter and surpassing analysts' forecasts by six cents.
What factors contribute to Teva Pharmaceutical's success?
To answer this objectively, it's essential to examine not only the impact of sales from individual medications but also to delve deeper into how effectively the company's management is handling the development of each of Teva's business segments.
We'll begin with the United States segment, which significantly influences Teva's financial standing. For the three months ending June 30, 2024, revenue in this segment reached $2.12 billion, reflecting an 11.5% year on year increase and a 22.3% rise from the previous quarter.
First, Teva's revenue and profit growth were largely fueled by significant advancements in its generics business, despite facing stiff competition from companies like Viatris (VTRS), Dr. Reddy's Laboratories (RDY), Perrigo (PRGO), and others in the market.
In the second quarter, total sales of generic products reached approximately $1.03 billion, marking a 26.6% increase from the previous quarter.
What factors led to the recovery of Teva's generics business?
The resurgence of Teva's generics business in the U.S. was primarily driven by the launch of an interchangeable biosimilar to AbbVie's Humira (ABBV), rising demand for generic versions of Bristol-Myers Squibb's Revlimid (BMY), a major blockbuster for treating multiple myeloma, the generic version of Novo Nordisk's Victoza (NVO) for type 2 diabetes, and the expansion of its drug portfolio.
The soaring sales of Copaxone and the strong performance of Austedo, which I analyzed in detail in a previous article, were also notable. Despite increasing competition in the U.S. tardive dyskinesia therapeutics market from Neurocrine Biosciences' (NBIX) Ingrezza, Austedo's demand continued to grow.
Sales of the Austedo franchise reached $407 million in the second quarter of 2024, a 32.1% YOY increase, driven by expanded patient access and the FDA's late May approval of Austedo XR in four new tablet strengths, giving doctors more options for optimizing treatment regimens for adults with tardive dyskinesia and Huntington's disease-associated chorea.
I also want to highlight Uzedy, a long-acting formulation of risperidone, as another key contributor to Teva's revenue growth. Although the company launched Uzedy in May 2023 and has not yet disclosed its sales figures, it has been approved for the treatment of schizophrenia.
However, as evident from the chart below, the total number of prescriptions has been steadily increasing month over month. Teva Pharmaceutical estimates that its revenue from Uzedy will be around $80 million in 2024, exceeding my expectations by approximately $25 million.
Despite ongoing growth in demand for this anti-CGRP migraine medication, its sales amounted to $42 million in the second quarter of 2024, a decrease of 6.7% compared to the previous quarter and 19.2% year-on-year. This decline was primarily due to an increase in sales allowances linked to a one-time event.
Now, let's turn our attention to the company's Europe segment, which generates most of its revenue through sales of generics and biosimilars.
For the three months ending June 30, 2024, sales in this segment reached approximately $1.21 billion, reflecting a 4.3% year-on-year increase, driven by new product launches and growing demand for Ajovy.
However, sales of respiratory medications continue to face challenges due to a decline in cold and flu cases. As anticipated, demand for Copaxone is weakening, not only because of competition from generic versions but also due to the availability of more effective treatments for relapsing forms of multiple sclerosis, such as Bristol-Myers Squibb's Zeposia, Roche Holding's Ocrevus and TG Therapeutics' Briumvi (TGTX).
Lastly, let's discuss the International Markets segment, which focuses on commercializing Teva's drugs across 35 countries, including Canada and Japan. In the second quarter, revenue for this segment was $593 million, representing a 2.6% YOY increase.
However, the segment's profit dropped significantly to $73 million quarter over quarter, due to declining demand for Copaxone, increased R&D expenses, and higher sales and marketing costs related to the distribution of Austedo in China.
The question arises: "Are there any positives?" The short answer is yes.
Teva's revenue from generic drugs has been on an upward trend in recent years, with the exception of the fourth quarter of 2023. For the three months ending June 30, 2024, it reached $488 million, marking a 2% increase from the previous quarter.
What is driving this sales growth?
Despite challenges such as the weakening of foreign currencies like the Japanese yen, ruble, and Chinese yuan against the US dollar, increased competition in Japan, and ongoing inflationary pressures on the pharmaceutical industry, Teva’s management has successfully navigated these obstacles by expanding its medication portfolio and raising prices.
Now lets talk about Risks
Several risks could negatively impact Teva Pharmaceutical’s investment appeal in the medium to long term. At the end of July, Teva reported financial results for the second quarter of 2024, which not only exceeded analysts' expectations but also reinforced confidence in the effectiveness of the business strategies implemented by CEO Richard Francis.
In addition to accelerating the recovery of the company's generics business, boosting sales of Austedo and Uzedy, and launching the Humira biosimilar in May, Teva also raised its full-year 2024 guidance.
With a P/E ratio of 6.35x, which suggests the stock is trading at a discount compared to the broader healthcare sector, other positives include the reduction of Teva’s net debt by about $2 billion over the past 12 months, as well as year-over-year growth in gross and operating profits.
To understand who truly holds control over Teva Pharmaceutical Industries Limited, it's crucial to examine the company's ownership structure. The largest share of ownership, approximately 69%, is held by institutional investors. This means that this group stands to experience the greatest potential for gains or losses, depending on the company's performance.
The company has also accelerated the development of its product candidates under its "Pivot to Growth" program, which aims to strengthen its balance sheet and enhance its investment appeal by expanding its biosimilar portfolio and bringing potential best-in-class drugs for cancer, neurological, and autoimmune disorders to market.
So TEVA Pharmaceutical is a BUY? YUP
PALANTIR Correction starting. Short or wait to buy on that levelPalantir Technologies (PLTR) have been trading within a Channel Up since the May 04 2023 Low. Last week the price reached the pattern's top (Higher Highs trend-line) and technically we expect that to be the end of the recent Bullish Leg, as also indicated by the Sine Waves.
Naturally we anticipate a medium-term pull-back in the form of a Bearish Leg. The previous 3 Bearish Legs have been under the form of Lower Highs that broke below the 1D MA50 (blue trend-line) and hit at least the 1D MA100 (green trend-line) before rebounding again into a new Bullish Leg.
As a result, we expect to see at least a test of the 1D MA100, which short sellers can target $26.00. This is also above the minimum %correction we've seen inside this pattern (-25.90%).
The strongest buy signal inside this long-term Channel Up is historically give when the 1D RSI hits the 35.85 - 30.20 Support Zone.
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VISA Best buy opportunity since 2022.Visa Inc (V) is trading again above its 1W MA50 (blue trend-line) for the 3rd straight week following the rebound on early August's Low. That low apart from a Double Bottom is also a technical Higher Low formed at the bottom of the 2-year Channel Up.
The previous Double Bottom in October 2023 was exactly on the 1W MA50 and even though not at the bottom of the Channel Up, it did manage to kickstart a +27.36% rally. The Bullish Leg before it rose by +34.04% before also correcting back to the 1W MA50.
With the 1W MACD about to form the first Bullish Cross in 9 months, we have at hand the best buy opportunity on Visa, whose last 1W MACD this low was back on the September 2022 bottom! Our Target for the end of the year is $320.00 (+27.36%).
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SMCI Short-term buy opportunity within its corrective Channel. Super Micro Computer Inc. (SMCI) has been trading within a Channel Down pattern since the March 08 2024 High. Even though the trend on a multi-year basis is bullish, short-term investors should have this pattern in mind.
Even on the shorter term though, the stock has managed to price a new Lower Low (August 08) at the bottom of the Channel Down and started its new Bullish Leg. Today's low opening has served as the first technical Higher Low on the Bullish Leg, potentially similar to the May 01 2024 Higher Low of that Channel Up.
The 1D MACD has already completed a Bullish Cross, as on May 06 and naturally the next Target is a Higher High above the 1D MA50 (blue trend-line) again. We are aiming for $750.00 short-term.
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How To Pick Top Pharma Stocks like a ProAnalyzing the pharmaceutical industry, whose products play a key role in improving the quality of life of people around the world, is quite challenging sometimes also it requires deep knowledge and a careful approach, as I believe that investors should consider many factors, starting with evaluating the efficacy of the analyzed company's medications, including in relation to its competitors and the "gold standards," and ending with an analysis of its financial indicators
In this article you will learn how to pick Top Pharma stocks like a pro trader and which factors you should consider, so buckle up
1/ Recognizing the risks
At the very beginning, an investor you must recognize that the pharmaceutical industry is highly competitive, where a company's investment attractiveness depends not only on the rate of expansion of its portfolio of product candidates, revenue growth, margins, the amount of total debt and cash on the balance sheet but is also heavily influenced by the expiration of patents on medications and vaccines.
Moreover, in recent months, the healthcare sector has increasingly felt the impact of the upcoming 2024 US presidential elections, as some politicians are aiming to further tighten regulation of drug prices despite the existing Inflation Reduction Act.
2/ Leveraging data to your advantage
The second step use data wisely, you should check all kinda data including stock screener, transcripts of earnings calls, financial results for the last quarters, analyst expectations, options data... The goal is to filter companies in poor financial condition, as well as those that trade at a significant premium to the sector and/or competitors
I would also like to point out that in the current market environment, with Fed interest rates remaining at multi year highs, I do not recommend investing in companies with market caps below $500 million, as they typically have limited cash reserves and weaker institutional backing
Also, I'd recommend investors read 10-Ks and 10-Qs, especially the section related to debt and sources of financing of the company's operations, to reduce the likelihood of an "unexpected" drop in the share price. A striking example is Invitae Corporation aka NVTAQ which declared bankruptcy in mid February 2024!
Was there a prerequisite for this? The answer is yes since the company continued to generate negative cash flow and also had convertible senior notes maturing in 2028.
Convertible notes can involve significant financial risks if the company cannot effectively use the cash to grow the business and break even. In this case, management will not be able to pay off the bonds with cash reserves and will have to resort to significant dilution of investors. In my opinion, Pacific Biosciences of California, Inc. NASDAQ:PACB may face this problem because it has convertible senior notes maturing in 2028 and 2030.
Factors that concern me include the company's declining revenue and total cash and short-term investments in recent quarters, while its operating expenses remain extremely high at around $80 million per quarter.
Let's return to the second step in my approach to selecting the most promising assets in the healthcare sector.
When selecting companies with market caps between $4 billion and $40 billion, I use more parameters since most of them already have FDA approved drugs and/or vaccines.
As a result, it is also necessary to consider the rate of growth of operating income, net debt/EBITDA ratio, and how management copes with increased marketing and production costs.
Finally, let's move on to the last basket, which contains pharmaceutical companies with market capitalizations exceeding $40 billion. I think, this group is best suited for more conservative investors looking for assets offering attractive dividend yields and growing net income, supported by a rich portfolio of FDA approved and experimental drugs.
So, from Big Pharma, I like Pfizer Inc NYSE:PFE , AbbVie Inc NYSE:ABBV , Merck & Co NYSE:MRK and AstraZeneca PLC NASDAQ:AZN . I also want to include Novartis AG NYSE:NVS and Roche Holding AG OTC:RHHBY in this group
sometimes investors need to make exceptions, namely if one larger company buys out a smaller player and/or when a major partnership agreement is concluded, as was the case between Merck and Daiichi Sankyo Company, Limited OTC:DSKYF in 2023.
Also, in the event of a major acquisition or merger, the company's debt may temporarily increase sharply. If its management has previously implemented effective R&D and financial policies, the "net debt/EBITDA ratio"
A remarkable example of a company falling into the "value trap" is Takeda Pharmaceutical Company Limited NYSE:TAK , which overpaid for Shire. This deal did not significantly strengthen or rejuvenate the Japanese company's portfolio of drugs.
As a result, it had to sell off billions of dollars in assets to pay off its debt partially. However, despite all the efforts of Takeda's management, its net debt/EBITDA ratio, although it fell below 5x, remains high, namely about 4.7x at the end of March 2024.
3/ Identifying promising therapeutic areas
In general, the more prevalent a disease is, the larger the total addressable market for a drug and, as a result, the higher the chances that it will become a commercially successful product.
Global spending on cancer medications will reach $377 billion by 2027, followed by immunology, and diabetes will come in third with an estimated spending of about $169 billion
What challenges arise when choosing pharmaceutical companies?
you should also keep in mind that the larger the market, the higher the competition between medicines, as companies strive to grab as big a piece of the pie as possible.
As a result, for drug sales to take off, they need to have significant competitive advantages over the "gold standard." These competitive advantages may include greater efficacy in treating a particular disease, less frequent administration, a more favorable safety profile, and a more convenient route of administration.
So, in recent years, competition in the global spinal muscular atrophy treatment market has intensified. Spinal muscular atrophy is a genetic condition. Currently, three drugs have been approved to combat the disorder, including Biogen Inc.'s (BIIB) Spinraza, Roche/PTC Therapeutics, Inc.'s (PTCT) Evrysdi, and Novartis AG's (NVS) gene therapy Zolgensma.
All three products have similar efficacy, but Evrysdi has a more favorable safety profile and is the more convenient route of administration, namely the oral route, which is reflected in its sales growth rate from year to year.
The second pitfall is the company's pipeline of experimental drugs.
I believe that financial market participants opening an investor presentation that presents a company's pipeline, especially if its market cap is below $5 billion, should also pay close attention to what stage of clinical trial activity its experimental drugs are in.
if a pharmaceutical company has most of its product candidates in the early stages of development, this represents a significant risk because, in this case, institutional and retail investors are often overly optimistic about the prospects for the drugs' mechanisms of action and/or clinical data obtained in a small group of patients. Simultaneously, as is often the case, the higher the optimism, the less favorable the risk/reward profile.
In most cases, the larger and more diverse the patient population, the weaker the efficacy of a drug relative to what was seen in Phase 1/2 clinical trials. This ultimately leads to a downward valuation of its likelihood of approval and casts doubt on its ability to take significant market share from approved medications.
This may subsequently reduce the company's investment attractiveness, making it more difficult to attract financing for its operating activities.
As a result, I recommend excluding any company that, instead of focusing its financial resources on the most promising product candidates, conducts multiple early-stage clinical trials to evaluate the efficacy of its experimental drugs.
In my experience, the most successful pharmaceutical companies focus their efforts on bringing up to three product candidates to market and then reinvesting the revenue from their commercialization into developing the rest of the pipeline.
The table below highlights the following parameters that I use to screen out the least promising companies.
A third factor that investors, especially those new to the investment world, should consider is that large pharmaceutical companies are leaders in certain therapeutic areas, with a rich portfolio of patents covering various mechanisms of action and delivery methods of drugs, making it more difficult and more prolonged for smaller players to find product candidates that could potentially have the competitive advantages.
So, Novo Nordisk A/S NYSE:NVO and Eli Lilly and Company NYSE:LLY have long been leaders in the global diabetes and weight loss drugs markets, and only very recently, they may be joined by Amgen Inc. NASDAQ:AMGN , Roche Holding, and several other companies
4/ Assessing a company's drug portfolio in comparison to competitors
Evaluating the effectiveness, safety profile, and mechanism of action of a medication, as well as comparing clinical data with its competitors, takes a lot of time and effort. I provided examples of drugs and the most promising mechanisms of action in the obesity treatment market. Their manufacturers are Eli Lilly, Novo Nordisk, Roche Holding, Viking Therapeutics, Inc, Amgen, Pfizer, Altimmune, Inc, OPKO Health, Inc, Boehringer Ingelheim, and Zealand Pharma A/S
5/ When market exclusivity for a company's key medications ends
Every financial market participant who is considering investing in pharmaceutical companies should consider the expiration time of key patents of medicines.
Marketing exclusivity represents protection against the entry of a generic version and/or biosimilar of a branded drug into the market, thereby allowing the company to recoup the resources spent on its development and, in the event of its commercial success, also reinvest the money received to accelerate the development of the remaining product candidates.
Where can you find information about patent expiration dates?
All the necessary information is either in 20-Fs/10-Ks or on the FDA website, namely in the "Orange Book" section. let's take Eli Lilly as an example. Open the latest 10-K. Then, the CTRL + F combination opens the ability to find specific words in the document. I usually enter "Expiry Date" or "compound patent" to find the patent section.nvestors can also find information about patents on the FDA website.
As an example, I enter "Mounjaro" in the top line, and a list of patents opens that protect Eli Lilly's blockbuster from the introduction of its generic versions onto the market.hen, clicking on "Appl. No." will open information about the submission date of the patent and when it will expire.
6/ Evaluating the impact of insider share transactions
The next step in selecting the most interesting assets in the healthcare sector is to analyze Form-4s. The CEO, CFO, and other key members of the company's management buy or sell shares from time to time.I am only interested in analyzing purchases since, most often, sales by management are option exercises carried out to pay taxes.
When management starts making large outright purchases of a company's shares, it can signal that it believes in its long-term growth potential.if more than two top managers buy a large block of shares within two weeks of each other, it significantly increases the likelihood of the company's stock price rising in the next two months from the moment of their transactions
But as with everything, there are exceptions, such as in the case of OPKO Health, which is developing a long-acting oxyntomodulin analog for the treatment of obesity together with LeaderMed Group.Over the past 12 months, OPKO's management, especially CEO Phillip Frost, has purchased over 12 million shares.
However, despite this, its stock price has fallen by 27% over the same period. I believe that the key reasons for the divergence between these two facts are investors' lack of confidence in Phillip Frost's ability to make the company profitable again, as well as its low cash reserves. Therefore, companies like OPKO Health have already been eliminated at the second step of selection using Seeking Alpha's screener.
7/ CEO Performance in Business Development
The CEO plays a crucial role in the success of a pharmaceutical company since the pharmaceutical industry is highly dynamic, and the competition between Big Pharma is especially high, I advise readers to pay attention to the track record of the CEO, especially how he copes with force majeure situations, as well as how effective the R&D policy is carried out under his leadership.
8/ Identifying Entry and Exit Points for Long-Term Investments
The eighth step is in addition to the information that was obtained in the previous steps, as well as the analysis of financial risks and various financial metrics of the company, including its net debt, maturity dates of bonds, historical revenue growth rates, EBIT, gross margin, I build a DCF model with the ultimate goal of determining the price target.
it is necessary to conduct a technical analysis of them, as well as the main ETFs that include them. In my opinion, the key ETFs are the SPDR® S&P Biotech ETF AMEX:XBI , Fidelity Blue Chip Growth ETF AMEX:FBCG , iShares Biotechnology ETF NASDAQ:IBB , and VanEck Pharmaceutical ETF $PPH. The purpose of technical analysis is to determine the stop-loss level and entry points at which the risk/reward profile is most favorable. taking profit is not that easy cuz you must master your emotions and greed which damn hard
9/ Creating a Watchlist Based on Risk/Reward Ratio
The purpose of which is to create a watchlist of the companies I have selected based on the previous steps. I make several lists of companies based on their market caps and also rank them according to risk/reward profile, that is, in the first place is the stock that I think has minimal risks and at the same time can bring the greatest potential profit.
I also advise creating small notes on each company, which can include information about risks, support/resistance zones, dates of publication of clinical data, and any thoughts you have that will make your decision more conscious when opening a position
“What’s your secret sauce for choosing pharma stocks?”
GOOGLE You can still catch this BUY to based on these indicatorsAlphabet Inc. (GOOG) is in the process of forming a bottom following the July and early August correction. Technically it has already priced the new Higher Low (green Arc) on the 20-month Channel Up but is underperforming relative to the rest of the tech sector.
This is why it hasn't yet broken above the 1D MA100 (green trend-line) but this isn't at all discouraging. Every break within this long-term Channel Up below the 1D MA100 and subsequent recovery above it, confirmed the start of its new Bullish Leg. This has only taken place when the 1D MACD formed a Bullish Cross below the 0.0 mark, which last took place on August 16.
The above occurrences indicate that it is not late to catch this unique long-term buy on Google. Following the October 27 2023 Low, the first High it made was after a +28.14% rise. As a result our first long-term Target is $200.
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Tencent Holdings LtdIs Tencent Stock a Buy Now?
Tencent posted its third quarter earnings report on Nov. 16. The Chinese tech giant's revenue fell 2% year over year to 140.1 billion yuan ($19.8 billion), which represented its second consecutive quarter of declining revenue since its IPO in 2004. Its net profit rose 1% to 39.9 billion yuan ($5.6 billion). On an adjusted basis, which excludes its investments and other one-time items, its net profit grew 2% to 32.3 billion yuan ($4.5 billion). Those growth rates seem anemic, but Tencent's stock had already been cut in half over the past two years amid concerns about China's tightening regulations, slowing economic growth, and COVID19 lockdowns. So is it the right time to take the contrarian view and buy Tencent as a turnaround play? Let's review its core businesses and valuations to decide.
Tencent generated 31% of its third quarter revenue from its video game business. Domestic games, which include its blockbuster game Honor of Kings, accounted for 73% of that total. The remaining 27% came from overseas hits like League of Legends, Valorant, and PUBG Mobile.Its domestic gaming revenue fell 7% year over year, representing its third consecutive quarter of shrinking revenue, as it grappled with tighter playtime restrictions for minors in China over the past year. Those restrictions also coincided with a temporary suspension on new video game approvals in China, which started last July and ended this April.Its international gaming revenue rose 3% year over year, accelerating from its 1% decline in the second quarter, as new games like Tower of Fantasy and Goddess of Victory: Nikke attracted new players. Unfortunately, its overseas growth still couldn't offset its declining domestic revenue.
As a result, Tencent's total VAS (value-added service) revenue which includes its gaming divisions, social media platforms, and streaming media subscriptions -- declined by 3% in the third quarter but still accounted for more than half of its top line. This core business might gradually stabilize as Tencent expands its international gaming business, but it will likely remain under intense pressure as long as the Chinese government continues to scrutinize the gaming industry.
200$ was one of the biggest support and great opportunity to buying the dip. 300-320$ is a big resistance level for tencent and if bulls win that battle then 350$ is next but
can we back 250 or even 200$ again? YES
Tata Elxsi can rise to old glory againTata Elxsi Limited, a part of Tata Group was incorporated in March 30th, 1989 as Tata Elxsi (India) Ltd. The Company is a global design and technology services company for product engineering and solution services across industries including Automotive, Broadcast, Communications, Healthcare, and Transportation. The operations are classified into two business divisions, i.e., Software Development and Services and Systems Integration and Support.
Tata Elxsi Limited CMP is 7088.15. The positive aspects of the company are Rising Net Cash Flow and Cash from Operating activity, It is a Company with No Debt and Company with Zero Promoter Pledge. The Negative aspects of the company are high PE (PE=56), MFs decreased their shareholding last quarter, declining profits and falling profit margins.
Entry can be taken after closing above 7132. Targets in the stock will be 7334, 7361, 7553 and 7797. The long-term target in the stock will be 8025, 8197, 8360 and 8539. Stop loss in the stock should be maintained at Closing below 6661.
The above information is provided for educational purpose, analysis and paper trading only. Please don't treat this as a buy or sell recommendation for the stock. We do not guarantee any success in highly volatile market or otherwise. Stock market investment is subject to market risks which include global and regional risks. We will not be responsible for any Profit or loss that may occur due to any financial decision taken based on any data provided in this message.
AMAZON Only a break above the 1D MA50 remains. $240 on sight.Amazon Inc. (AMZN) spent the previous 2 weeks on a very strong recovery of the losses sustained in July - August, in fact those have been the strongest 2-week candles since October 23 - 30 2023.
That was the previous bottom of the 2.5 year Channel Up on its Higher Lows trend-line. Even though the stock broke below the 1W MA50 (blue trend-line) for the first time in more than 1 year (May 2023), it managed to hold the long term Support of the 1W MA200 (orange trend-line).
As this 1W chart shows, the Higher Lows of this pattern are periodic and cyclical and you can see that clearly with the use of the Sine Waves (also evident on the 1W RSI, the green circle bottoms below its MA). Every time the price broke above the 1D MA50 (red trend-line) following such a Low (3 times) it approached the top of the Channel Up.
The first Bullish Leg peaked at +79%, the second at +69%. If this is a progressive sequence, then the third (current) Bullish Leg could be -10% less than the last, i.e. +59%. As a result, the 1D MA50 (which applied high selling pressure this week), is the final Resistance and bullish break-out confirmation the price technically needs before it targets $240.00 (+59% rise).
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