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$LPTX Leap Therapeutics, Inc., a biopharmaceutical company, acquires and develops therapies for the treatment of cancer. Its lead clinical stage programs include DKN-01, a monoclonal antibody that inhibits Dickkopf-related protein 1 that is in multiple clinical trials for treating esophagogastric cancer, hepatobiliary cancer, gynecologic cancers, and prostate cancer. The company was formerly known as HealthCare Pharmaceuticals, Inc. and changed its name to Leap Therapeutics, Inc. in November 2015. Leap Therapeutics, Inc. was incorporated in 2011 and is based in Cambridge, Massachusetts. Leap Therapeutics Presents Updated Positive Data from the DisTinGuish Study of DKN-01 Plus Tislelizumab at the ESMO Congress - DKN-01 plus tislelizumab and chemotherapy demonstrated compelling activity in first-line patients with gastric or gastroesophageal junction cancer - Additional data presented today showed responses to treatment are independent of PD-L1 expression, with 79% ORR in patients with PD-L1 low (CPS < 5) tumors - Company to host conference call on Friday, September 17, 2021 at 8:00 a.m. ET CAMBRIDGE, Mass., Sept. 16, 2021 /PRNewswire/ -- Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today announced the presentation of updated positive data from the first-line cohort of the DisTinGuish study, a Phase 2a clinical trial evaluating Leap's anti-Dickkopf-1 (DKK1) antibody, DKN-01, in combination with tislelizumab, BeiGene Ltd.'s anti-PD-1 antibody, and chemotherapy, in patients with gastric or gastroesophageal junction cancer (G/GEJ), at the European Society for Medical Oncology (ESMO) Congress. The Company will host a conference call on Friday, September 17, 2021 to discuss preliminary results from the study. The Company announced positive initial data from the DisTinGuish study on Monday, September 13, 2021 based on 25 G/GEJ patients enrolled in the trial that showed DKN-01 in combination with tislelizumab and chemotherapy as first-line therapy was well tolerated with compelling activity. The results presented at the ESMO Congress today included additional patient data stratified by tumoral PD-L1 expression levels based on visually-estimated combined positive score (vCPS), showing that robust objective clinical responses can be achieved from this combination regimen independently of PD-L1 expression. "Initial data from this trial have shown that patients with high levels of DKK1 expression, a group with a poor prognosis, had encouraging responses to treatment. The additional data presented today show evidence that not only is DKK1 a critical biomarker in predicting response to DKN-01 and tislelizumab therapy, but also that the combination can induce deep responses regardless of the patient's PD-L1 status, including particularly poor prognosis patients with both low PD-L1 and high DKK1," said Samuel Klempner, MD, Member of the Faculty at Massachusetts General Hospital Cancer Center and Harvard Medical School. "Taken together, these are promising results for the combination therapy of DKN-01 with tislelizumab and chemotherapy in first line patients with gastric or gastroesophageal junction cancers." About the DisTinGuish Study The DisTinGuish study (NCT04363801) is a Phase 2a study of DKN-01 in combination with tislelizumab, an anti-PD-1 antibody, with or without chemotherapy as first-line or second-line therapy in patients with inoperable, locally advanced, G/GEJ adenocarcinoma. The study is being conducted in two parts in the United States and the Republic of Korea. Enrollment of Part A has been completed with 25 first-line HER2- G/GEJ cancer patients whose tumors express either high levels of DKK1 (DKK1-high) or low levels of DKK1 (DKK1-low). Part B of the study will enroll up to 48 patients with second-line, DKK1-high G/GEJ cancer. Leap is conducting this combination study as part of an exclusive option and license agreement with BeiGene for the development of DKN-01 in Asia (excluding Japan), Australia, and New Zealand. Key Findings Among patients who received a full cycle of DKN-01 therapy, the ORR was 68.2%, with 90% ORR in DKK1-high patients and 56% in DKK1-low patients Response was independent of PD-L1 expression, and particularly strong in the less favorable to checkpoint inhibitor therapy, PD-L1 low (vCPS < 5), population DKK1 expression and PD-L1 expression are not correlated Median duration of response and progression-free survival data are not yet mature, and patient follow-up continues Twenty-five first-line patients were enrolled, and as of the cut-off date of the presentation, 15 patients had experienced a partial response (PR), six patients had a best response of stable disease (SD), one patient was non-evaluable for response (NE), and three patients were unable to complete a full cycle of DKN-01 therapy (non-modified ITT (mITT)). Among the 21 patients that had RNAscope® DKK1 expression available, 12 were DKK1-high and 9 were DKK1-low . Among the 20 patients that had PD-L1 expression available, 14 were PD-L1 low vCPS < 5 and 6 were PD-L1 high vCPS > 5 . A copy of the poster presentation is available on the Company's website at www.leaptx.com Conference Call Leap will host a conference call on Friday, September 17, 2021 at 8:00 a.m. Eastern Time to further discuss the data. In addition to Leap's executive management team, Dr. Jaffer Ajani of M.D. Anderson Cancer Center and Dr. Samuel Klempner of Massachusetts General Hospital will be on the call. The call can be accessed by dialing (866) 589-0108 (U.S. and Canada) or (409) 231-2048 (international). The passcode for the conference call is 1729397. The presentation will be webcast live and may be accessed on the Investors page of the Company's website at investors.leaptx.com where a replay of the event will also be available for a limited time. About Leap Therapeutics Leap Therapeutics (Nasdaq: LPTX) is focused on developing targeted and immuno-oncology therapeutics. Leap's most advanced clinical candidate, DKN-01, is a humanized monoclonal antibody targeting the Dickkopf-1 (DKK1) protein. DKN-01 is in clinical trials in patients with esophagogastric, hepatobiliary, gynecologic, and prostate cancers. Leap has entered into a strategic partnership with BeiGene, Ltd. for the rights to develop DKN-01 in Asia (excluding Japan), Australia, and New Zealand.
NASDAQ:LPTXLong
by BADQOMOCAWGOWLD
1
Ethereum 40% CrashOn May 19th, Ethereum (ETH/USD) suffered its biggest-ever one-day loss, sliding 47% before bouncing to finish the session lower by 28%. The following day, the recovery continued with a 14% rally. However, on the 21st, when the bulls were starting to get comfortable, ETH embarked on a three-day slide that wiped 40% from its value and ushered in two months of misery. September 7th, ETH dropped 25% intraday before rebounding into the close to pare the loss to 13.7%. On Wednesday, the recovery continued, and Ethereum improved by 6%. However, yesterday, the price tracked back to the previous days opening price. But what’s interesting is that if we scroll back to May’s drop, we see a similar pattern emerging. The closing price on the 21st was the same as the 19ths. Furthermore, the highs of the 20th and 21st are within $50 of each other. Thursday’s closing price of $3,424 is almost a perfect match with Tuesday’s $3,433 close. Not to mention that the highs from Wednesday and yesterday are within $20 of each other. So far, the analog is near on exact. Now here is where it gets weirder. Turning to the weekly chart, more similarities are evident. In the first week of May, the Ethereum price jumped 33% to a new all-time high of $4,085 before finishing the week at $3,928. The following week, ETH advanced to a new $4,646 before reversing 22% to close the weekly candle at $3,585. The week after, the price halved. In the first week of September, the Ethereum Price gained 28% to $4,087 ($2 above the first weekly close of May) and settled at $3,952, just $24 above the same week in May. Until this weekly candle is completed, we won’t know for sure if the redux will remain intact. But if it does, it’s worth noting what happened in the third week of May. Of course, it’s too early to suggest the price will collapse in the next few days. But it’s also too early to assume that ETH will continue higher. As mark twain said, “History never repeats, but it does often rhyme.”
by betsygain738
3
Education excerpt: Relative Strength IndexEducation excerpt: Relative Strength Index General information The Relative Strength Index ( RSI ) is a momentum oscillator that was introduced by J. Welles Wilder in an article published in Commodities magazine in June 1978. The Relative Strength Index measures the velocity of directional price movement and is commonly used in conjunction with a daily bar chart. However, it can be utilized on a bar chart with any particular time frame. The concept of this oscillator is based upon an idea of an asset being oversold or overbought. Generally, tops and bottoms are indicated when the RSI goes above 70 or drops below 30. Although, failure swings above 70 or below 30 can imply possible market reversal. Similarly, divergence between the RSI and price action on the chart can signal a market turning point. Chart formations and support and resistance often show up graphically on the RSI despite the fact that they may not be apparent on the bar chart. The slope of the momentum oscillator is directly proportional to the velocity of the move. Thus, the distance traveled up or down by the RSI is proportional to the magnitude of the move. The horizontal axis represents time and the vertical axis represents distance traveled by the indicator. The RSI moves slowly when the market continues its directional movement . However, once price is at the market turning point, RSI tends to move faster. Calculation The Relative Strength Index is commonly calculated using the close price of a 14 day period. The equation for its calculation involves several components. These are: • Average up closes • Average down closes • Relative strength Relative Strength ( RS ) = (average of 14 day's closes up/average of 14 day's closes down) Relative Strength Index ( RSI ) = 100 – Calculation begins with obtaining the sum of the up closes for the previous 14 days. This sum is then divided by the number of days used in calculating the generating figure for average up closes. Similarly, the sum of the down closes for the previous 14 days is divided by the number of days used in calculating the generating figure for average down closes. After these two operations are conducted, the average up days are divided by the average down days resulting in the value of the Relative Strength ( RS ). The number 1 is then added to the value of RS . Next, 100 is divided by the new amount of RS . The resulting figure is subsequently subtracted by 100 generating the value of the Relative Strength Index ( RSI ). From this step on, the previous value of average up closes and average down closes can be used to generate the next value of the RSI . In order to calculate the next average up close, the previous value of average up closes is multiplied by 13 and the present day average up close is added to this figure. This value is then divided by 14 generating the value for the new average up closes. In similar fashion, the new average down close is calculated by multiplying the previous average down closes by 13. Today's down close is then added to the figure. The resulting figure is again divided by 14 to generate the new average down close. After that, the same steps indicated to calculate the initial RSI need to be followed. Divergence When trend is prevalent and two indexes (or index and price) are going simultaneously either up or down they exhibit positive correlation. However, when this correlation breaks and one index (or price) keeps going up while another index reverses down divergence is said to occur. Technical analyst should pay attention to this instance as it sometimes has abillity to foreshadow upcoming reversal in trend. Though, there are many instances when divergence occurs and reversal in price trend fails to materialize. For this reason some analysts like to implement concept of double divergence. Double divergence There are many instances when price continues its rise and analyst can observe oscillator or idex to fall only to see it later climb back up in tandem with price. (same applies to the opposite situation when price falls and index or oscillator starts to rise) The divergence occured but price trend remained intact. Because the divergence can be misleading, some analysts preffer to wait for the second divergence before placing their entries or exits. Disclaimer: This content serves only educational purpose.
BITSTAMP:BTCUSDEducation
by fxpremiere
Education excerpt: Relative Strength IndexGeneral information The Relative Strength Index (RSI) is a momentum oscillator that was introduced by J. Welles Wilder in an article published in Commodities magazine in June 1978. The Relative Strength Index measures the velocity of directional price movement and is commonly used in conjunction with a daily bar chart. However, it can be utilized on a bar chart with any particular time frame. The concept of this oscillator is based upon an idea of an asset being oversold or overbought. Generally, tops and bottoms are indicated when the RSI goes above 70 or drops below 30. Although, failure swings above 70 or below 30 can imply possible market reversal. Similarly, divergence between the RSI and price action on the chart can signal a market turning point. Chart formations and support and resistance often show up graphically on the RSI despite the fact that they may not be apparent on the bar chart. The slope of the momentum oscillator is directly proportional to the velocity of the move. Thus, the distance traveled up or down by the RSI is proportional to the magnitude of the move. The horizontal axis represents time and the vertical axis represents distance traveled by the indicator. The RSI moves slowly when the market continues its directional movement. However, once price is at the market turning point, RSI tends to move faster. Here is depiction of the weekly chart of USOIL: It is clearly observable that peak in RSI often coincides with peak in the price. Similarly, trough in RSI is often accompanied by trough in the price. Calculation The Relative Strength Index is commonly calculated using the close price of a 14 day period. The equation for its calculation involves several components. These are: • Average up closes • Average down closes • Relative strength Relative Strength (RS) = (average of 14 day's closes up/average of 14 day's closes down) Relative Strength Index (RSI) = 100 – Calculation begins with obtaining the sum of the up closes for the previous 14 days. This sum is then divided by the number of days used in calculating the generating figure for average up closes. Similarly, the sum of the down closes for the previous 14 days is divided by the number of days used in calculating the generating figure for average down closes. After these two operations are conducted, the average up days are divided by the average down days resulting in the value of the Relative Strength (RS). The number 1 is then added to the value of RS. Next, 100 is divided by the new amount of RS. The resulting figure is subsequently subtracted by 100 generating the value of the Relative Strength Index (RSI). From this step on, the previous value of average up closes and average down closes can be used to generate the next value of the RSI. In order to calculate the next average up close, the previous value of average up closes is multiplied by 13 and the present day average up close is added to this figure. This value is then divided by 14 generating the value for the new average up closes. In similar fashion, the new average down close is calculated by multiplying the previous average down closes by 13. Today's down close is then added to the figure. The resulting figure is again divided by 14 to generate the new average down close. After that, the same steps indicated to calculate the initial RSI need to be followed. Here is depiction of the monthly chart of copper futures market: Similarly like in the previous example positive correlation between peaks and troughs in RSI and price is observable. Divergence When trend is prevalent and two indexes (or index and price) are going simultaneously either up or down they exhibit positive correlation. However, when this correlation breaks and one index (or price) keeps going up while another index reverses down divergence is said to occur. Technical analyst should pay attention to this instance as it sometimes has abillity to foreshadow upcoming reversal in trend. Though, there are many instances when divergence occurs and reversal in price trend fails to materialize. For this reason some analysts like to implement concept of double divergence. Here is example of the divergence that we mentioned in our idea on 30th June 2021: Double divergence There are many instances when price continues its rise and analyst can observe oscillator or idex to fall only to see it later climb back up in tandem with price. (same applies to the opposite situation when price falls and index or oscillator starts to rise) The divergence occured but price trend remained intact. Because the divergence can be misleading, some analysts preffer to wait for the second divergence before placing their entries or exits. Disclaimer: This content serves only educational purpose.
OANDA:XAUUSDEducation
by Tradersweekly
43
BTC 1D TAAs we can see on the chart, the curved price action shows a slowdown in momentum, Just like we saw when we reached the 60K zone before crushing down to the 30K zone. The curve of the price shows that there is less bullish fuel that moves the price up, and price stops moving as significantly as before. It does not necessarily mean a trend reversal is to come, but rather a healthy correction, especially after a long pump with zero to small pullbacks. Right now we're testing agian the important 50K res. A rejection of that level could be bearish, especially when it could form a double top on the 4H chart. As resistance we meet is the golden pocket (0.618-0.65 fibonacci levels), and right below us we hold 0.5 fibonacci level. We’re going to have to make a decision and break one of those fibonacci levels. A break above the golden pocket could indicate that the bulls start to gain more dominance, to the point of breaking that important resistance level, which also almost perfectly correlates with the 50K psychological level. A break below 0.5 fibonacci level could indicate a potential dip\trend reversal. We must remember that we still might create a lower high compared to the ATH. A significant reverse could indicate that there aren’t enough bulls to change the entire trend we started back in April 2021. If a pullback occurs it might hold the 42,450- 43,730 support zone. We also want to consider the fact that we have decreasing volume while price goes up, and generally speaking no strong volume. We’ve got an RSI bearish divergence, which correlates with the rest of the weakness shown in the market. This weakness may cause just a dip\ consolidation before moving up again. And just as I said before, a break above the 50K level and the golden pocket could easily bring us back to the ATH zone. Thank you for reading :)
by sunshine832
3
TradingView Hotkeys That I Use The MostHi, Just wanted to point out some TradingView hotkeys that I use the most: * ALT + H = Horizontal line - a great way to quickly mark the round numbers on your chart or tight support/resistance areas. * ALT + V = Vertical line * ALT + T = Trendline * ALT + I = Invert the chart - probably the most interesting hotkey. Do you have some trouble taking "SELL" ideas? You are more kinda "BUY-guy" or vice-versa. In TradingView you can turn your chart upside down and see does it look good if you would want to buy it. Sometimes, it is quite a big help. * ALT + S = Take a screenshot of your chart * ALT + F = Fibonacci * ALT + W = Put the chart to the watchlist - seeing something interesting you can add it quickly to your watchlist. * ALT + A = Set the alert * SHIFT + CLICK = Measure tool Regards, Vaido
COINBASE:BTCUSDEducation
by VaidoVeek
99
$WISH Analysis & Key levels$WISH Analysis & Key levels I do prefer stocks with more established technicals (there’s really not any support here)… but this one is on my radar today too… Could have an attractive upside - especially in the short term ——— I have WAY too many positions to be able to update on … So I’m just going to start posting the most recent support and key levels… Red = Key levels Green = resistance Blue = trendlines Have fun, y’all!!
WLong
by SPYder_QQQueen_Trading
1
BITCOINWe should take into the consideration the current wave formation. There are are literally countless ways to interpret it, but I will try to think of reasonable scenarios. 1 - Current wave is a B in ABC formation. If that is correct then it would cause another big wave down to sub 20k. I don't think it is probable. 2 - Current wave is Wave 1 in a new cycle If it is correct then: Wave 1 might be completed with small 5th and bigger correction might be possible to the major support at 40-42k or even in an area of a TR or lower support. (wave one can retrace up to 100% of the original move. Even if this scenario is possible, I don't think it is probable after such a strong impulse. Furthermore it is 50% retracement from large move down - quite heavy resistance so it is also possible that the correction will take place as a trading range for a while. (it means altcoins will perform better) If wave 1 is not complete and sub-wave 5 is still in formation, which might lead to 50-52k before larger correction. It would coincide with a measured move from impulse sub-wave 1 and also 0.618 fib levels. This is all part of hypothesis 2. There are also other 3 possible hypotheses for bitcoin price action. 1 - Price will continue to go up within the bull channel for extended period of time. I think it is less probable. 3 - It will ignore closest major support and retrace all the way down to 30k or somewhere in between 30-40k (trading range square) before bouncing up. 4 - Price will decide that latest impulse was in fact a B in ABC correction and will continue to go down towards 20k levels. Another way to look at it if it is actually a wave 3 in 5 wave cycle (if cycle started at the lowest point of the structure (marked red). However I would prefer the start from the wedge bottom, as the last wave of the correction might be truncated (couldn't breach the bottom). Anyway, if the strong impulse is wave 3 and it is completed or even if not (5th wave is in formation), then possible positive scenarios (blue arrows) are the same as if it is wave 1. Red arrows here are not possible as it would negate the 5wave structure at this point (correctional wave 4 is cant reach impulse wave 1). The major thing that differs from original hypothesis 2, that this wave 3 can possibly extend and have an enormously strong impulse up (for example back to all time highs. I think hypothesis 2 has most probability, because going down by retracing 100% after such a strong impulse move is unlikely. Bears simply are not strong enough after such strong upside. Furthermore I think that there is a bigger chance, that ABC has already formed and bottom at 30k is set. In a short term we might see some trading range or down action, but medium term I would be LONG, nevertheless also evaluating other scenarios if price action would go in the 'not probable' zone.
Long
by Sharkethics
1
BTC TATechnical Analysis of BTC using 200DMA and 128DMA. BTC has tested and retested 200DMA as well as the 2.618 Golden Ratio Ext and is currently being rejected. There is tough resistances on HTF going into the 48-51k region. Bollinger Band width has been compared with RSI, when RSI and BBW touch and deviate with RSI trending up BBW trending down, we see and increase in price. The converse is true for decending price action. Two simple paths have been laid out (time frame is not considered, this is rough).
BINANCE:BTCUSD.PLong
by Ukuria
$F Target 15.47 for 14.93%$F Target 15.47 for 14.93% This kind of messed with me today… a long trendline broken… but also caught by support… WOW… this TA stuff NEVER gets old… let's see what happens... place your bets... ----- — On the far right of the chart is my Average (Grey) Current Target (Green), and Next Level to add (Red) Percentage to target is from my average. ONLY ADD at support levels & FIB levels… labeled I start every position with .5 - 1% of my account and build from there as needed and as possible. I am not your financial advisor. Watch my setups first before you jump in… My trade set ups work very well and they are for my personal reference and if you decide to trade them you do so at your own risk. I will gladly answer questions to the best of my knowledge but ultimately the risk is on you. I will update targets as needed. GL and happy trading.
NYSE:FLong
by SPYder_QQQueen_Trading
4