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Candel Therapeutics, Inc.Candel Therapeutics, Inc.Candel Therapeutics, Inc.

Candel Therapeutics, Inc.

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Candel Therapeutics Stock ($CADL) Soars 352%Introduction: In a groundbreaking development in the fight against pancreatic cancer, Candel Therapeutics ( NASDAQ:CADL ) has unveiled compelling data from its phase 2 clinical trial of CAN-2409. The therapy, designed to stimulate a robust anti-tumoral immune response, has demonstrated unprecedented improvements in survival rates among patients with non-metastatic pancreatic ductal adenocarcinoma (PDAC). With survival rates nearly tripling compared to standard-of-care (SoC) chemotherapy, CAN-2409 offers hope to patients facing this aggressive and notoriously difficult-to-treat cancer. The news led NASDAQ:CADL stock to surge with about 352% but is down by 4% as at the time of writing. Unveiling the Data: Candel Therapeutics ( NASDAQ:CADL ) recently announced updated interim data from its randomized phase 2 clinical trial of CAN-2409. The results, presented at the 2024 Society for Immunotherapy Annual Meeting, revealed staggering improvements in survival outcomes for patients with borderline resectable PDAC. The estimated median overall survival soared to 28.8 months among patients receiving CAN-2409, compared to a mere 12.5 months in the control group treated with SoC chemotherapy alone. Moreover, at the 24-month mark, a remarkable 71.4% of CAN-2409-treated patients were still alive, contrasting starkly with the control group's survival rate of only 16.7%. Even at 36 months, the survival advantage persisted, with 47.6% of CAN-2409 recipients still alive, underscoring the therapy's potential to provide durable benefits for PDAC patients. Mechanism of Action: CAN-2409 operates by activating a potent anti-tumoral immune response within the pancreatic tumor microenvironment. Analysis of resected tumors revealed dense aggregates of immune cells, including cytotoxic tumor-infiltrating lymphocytes and dendritic cells, indicative of heightened immunogenicity following CAN-2409 administration. These findings suggest that CAN-2409 effectively harnesses the patient's own immune system to target and eradicate cancerous cells, thus offering a novel approach to combatting PDAC's formidable resistance mechanisms. Safety Profile: Crucially, CAN-2409 exhibited a favorable safety profile throughout the trial, with no dose-limiting toxicities or instances of pancreatitis reported. This underscores the therapy's potential to be administered safely alongside standard chemoradiation protocols, offering a promising avenue for integration into current treatment regimens for PDAC patients. Implications for the Future: The promising results from Candel Therapeutics' phase 2 trial of CAN-2409 represent a significant stride forward in the quest to improve outcomes for pancreatic cancer patients. With the therapy's ability to prolong and sustain survival rates, even in the face of a disease notorious for its aggressive nature and poor prognosis, CAN-2409 holds immense promise as a potential game-changer in the field of pancreatic cancer therapeutics. Looking ahead, further clinical investigations and regulatory approvals will be crucial in bringing this innovative therapy to the forefront of pancreatic cancer treatment paradigms. If successful, CAN-2409 has the potential to revolutionize the standard of care for PDAC patients, offering newfound hope and extending lifespans for those grappling with this devastating disease. Technical Outlook Despite the spike in price by 352%, Candel Therapeutics NASDAQ:CADL is down by 7% in early premarket trading on Friday. the stock is trading above the 200-day Moving Average (MA) with a Relative Strength Index (RSI) of 88.50 indicating a strong overbought position for the stock.
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by DEXWireNews